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Born in 2007 from a project of Prof. Antonio Negro (1908 - 2010), founder of the Italian Academy of Homeopathy, the Museum preserves material of historical interest, such as the private Archives of homeopathic physicians of the 19th and 20th centuries, arrived by donation or entrusting (Pompilj Archive, Tosi Archive, Galatzer Archive, Negro Archive).

It also preserves a rich collection of Memorabilia and Documents related to homeopathic medicine of the 19th and 20th centuries. Interesting is the collection of Kits or Trousse of homeopathic medicines (over 200 examples).

The Museum's Library includes a rich collection of homeopathy texts (in Italian, German, French, English and Spanish). Of particular importance is the section on Hahnemannian medicine with rare first editions and the ancient Italian section on volumes published in Italy in the 1800s, the subject of a scientific monograph edited by the Museum.